Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics
By: Moore A, Crossley A, Ng B, Phillips L, Sancak O, Rainsford KD.
Journal of Pharmacy and Pharmacology 2017; Oct;69(10):1364-1373.
Summary: To test the ability of a multicriteria decision analysis (MCDA) model to incorporate data sources of varying quality (along with clinical judgement) in a benefit-risk assessment of six well-known pain relief drugs. Six OTC analgesics were evaluated against three favourable effects and eight unfavourable effects by experts who specialize in the relief of pain. Ibuprofen emerged with the best benefit-risk profile, followed by naproxen, ibuprofen, diclofenac, paracetamol and aspirin.