SelfCare Focus: a selection of newly published papers on self-care from the worldwide literature. 3. Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months

Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months.

By: Ziesenitz VC, Zutter A, Erb TO, van den Anker JN.

Pediatric Drugs. 2017 Aug;19(4):277-290.

Summary: Although there are extensive data on ibuprofen efficacy and safety in children and adults, there are divergent dosing recommendations for analgesia and treatment of fever in infants, especially in the age group between 3 and 6 months of age. In this article, the authors assess the safety and efficacy of ibuprofen use in infants in an attempt to find the optimal method of pain and fever management in this specific age group. Based on the current evidence, short-term use of ibuprofen is considered safe in infants older than 3 months of age having a body weight above 5-6 kg when special attention is given to the hydration of the patient. Ibuprofen should be prescribed based on body weight using a dose of 5-10 mg/kg. This dose can be administered 3-4 times a day resulting in a maximum total daily dose of 30-40 mg/kg. The rectal route has been shown to be less reliable because of erratic absorption, especially in young infants.

Abstract.

 

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