Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.
By: Bertoldi AD, Rifas-Shiman SL, Boing AC, da Silva Dal Pizzol T, Miranda VIA et al.
Paediatric and Perinatal Epidemiology 2020 Jan 22. doi: 10.1111/ppe.12632. Online ahead of print.
Summary: Over-the-counter analgesic use during pregnancy, particularly acetaminophen, may be associated with negative developmental outcomes in children. The American Project Viva cohort (1217 mother-child pairs enrolled 1999-2002) assessed cognition at approximately 3 years using the Peabody Picture Vocabulary Test and the Wide Range Achievement of Visual Motor Abilities (WRAVMA). The Brazilian 2015 Pelotas Birth Cohort (3818 mother-child pairs) assessed cognition at 2 years using the INTERGROWTH-21st Neurodevelopment Assessment. In Project Viva, exposure to acetaminophen in both the 1st and 2nd trimester of pregnancy was associated with lower WRAVMA drawing scores. However, in Pelotas, exposure to acetaminophen in both the 1st and 2nd trimester of pregnancy was not associated with INTER-NDA motor scores and was associated with higher INTER-NDA total scores.