Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication?
By: Idris A, Kaye K.
American Journal of Emergency Medicine. 2018 May 18. pii: S0735-6757(18)30404-2..
Summary: Loperamide is generally thought to be safe and effective without the potential for abuse. However, recent discovery of its ability to treat opioid withdrawal symptoms at high doses has led to not only its abuse, but also the need to recognize its cardiotoxicity due to the ability to prolong the QTc interval. This is a case report of a 33 year old female with a history of opioid dependence. The patient admitted to ingestion of 70 loperamide pills daily for the past year in order to alleviate her opioid withdrawal symptoms.